And just to clarify, it's not necessary to run all 4 outputs from the ECG-DR4 with HyperDMX. You could run one output in "normal" DMX mode, and the other 3 in HyperDMX mode.
The real difference, other than the unique start codes to separate universes, is the speed at which the data is sent down the wire to the devices. HyperDMX "speeds up" the timing, to send more in the same time interval.
The DMX standard has specific timings. These are violated by HyperDMX, and a normal DMX device may or may not respond to the faster timing, which means they are not compatible on the same output.
For those of us with the 8 way ECG-DMXRen8, we can output more DMX universes on more outputs, but there's a bandwidth limitation maximum that still is in effect, so we can't run more than 4 HyperDMX outputs at full speed.