LOR controllers will work with any free software like vixen and HLS using the DMX output as the LOR controllers can use DMX input, so your choices of sequence programs can be anything as long as it supports the standard DMX protocol
Pretty well every sequencer (except lower and older versions of LOR) will generate DMX either through a usb-dmx dongle or via an E1.31 to DMX (and possibly pixel) bridge. As long as the LOR boards have late (latish) firmware in them they will run in dmx mode so all that would be required is to put in a crossover board or cable as most dmx outputs use the ESTA pinout rather than LOR.
Options that I can think of easily are
Advatek Pixlite 16 -E1.31 to 16 pixel outputs and 4 DMX outputs
J1Sys D2 - E1.31 to 2 DMX outputs
J1Sys P12 - E1.31 to 12 pixel outputs and 1 DMX output
If you are only wanting to use your LOR controllers in DMX and not using any pixels then give your LOR dongle a try using DMX. The LOR dongle is compatible as an open DMX dongle.
If you want to use pixels as well then the choices already mentioned will do what you want as those controller also have a DMX output.